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Speaker Information

Professor Christopher Rudd
Professor Christopher Rudd Professor of Molecular Immunology University of Cambridge


Main Conference Day 2

2:10 PM Improving Survival with T Cell Clonotype Stability After Anti–CTLA-4 Treatment in Cancer Patients

• Cytotoxic T lymphocyte–associated antigen-4 (CTLA-4)
blockade can promote antitumor T cell immunity and clinical
responses
• Determine the effects of CTLA-4 blockade on the T cell
repertoire using next-generation deep sequencing to measure
the frequency of individual rearranged T cell receptor
β (TCRβ) genes
• Discover how this treatment can increase TCR diversity as
reflected in the number of unique TCR clonotypes

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